Functional modulation of the transient outward current Ito by KCNE β-subunits and regional distribution in human non-failing and failing hearts
نویسندگان
چکیده
a Medical Faculty, Dresden University of Technology, Fetscherstr. 74, Dresden, 01307 Germany b Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, 6701 Hungary c Department of Pharmacology & Pharmacotherapy, Faculty of Medicine, University of Szeged, Dom ter 12, Szeged, 6701 Hungary d Virginia Commonwealth University, Department of Physiology-Box 980551, Richmond, Virginia 23298-055, USA
منابع مشابه
Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts.
OBJECTIVES The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I(to) in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5. Here we aimed to determine the regional expression of Kv4.3, KChIP2, and KCNE mRNAs in non-failing and failing human hearts and to investigate the functional consequences of subunit coexpression in he...
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